How Long Can Botox Be Out of the Refrigerator?
Allergan confirmed that Botox could safely be out of the refrigerator for five days at room temperature. The good news does not end there, however. Besides remaining stable for much longer than expected and at more extreme temperatures, studies have also shown that you can use the reconstituted Botox for much longer than the packaging recommends. So if there are scheduling challenges, you can still use your reconstituted Botox safely for days or even weeks after you reconstituted it. The effectiveness remains the same, and the effect lasts for the same time as freshly reconstituted Botox.
After comparing the effectiveness of freshly reconstituted Botox solutions with those that were two hours, six days, one week, and four weeks old, respectively, researchers found that the results were statistically similar.
They injected volunteers with fresh and aged solutions in the extensor dithorium brevis muscles of their feet. Results showed that the two-hour old solution produced the same effects as the four-week-old solution. What's more? The solutions maintained their intended effects for just as long.
Other studies showed that Botox solutions that were up to 43 days old remained effective. Moreover, the results were similar when the solution was administered into glabellar lines, and the results were compared with freshly-prepared solutions. This shows that you can keep your solution for that length of time and not worry about adverse effects.
A caveat, though: to achieve the same kinds of results as these researches, you need to keep the reconstituted solutions refrigerated at +4oC. A dedicated medical refrigerator will help you to accomplish this easily. To get even better results with refrigerating your Botox solutions, you need to ensure a stable and uninterrupted power supply for your refrigerator.